VETERINARY MICROBIOLOGY & PARASITOLOGY COURSE SYNOPSIS

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VETERINARY MICROBIOLOGY & PARASITOLOGY

VPM 302: INTRODUCTORY VETERINARY MICROBIOLOGY AND MYCOLOGY    (2 Units)
History of microbiology. Introduction to bacteriology, mycology and virology. Morphology, variation and classification of bacteria, fungi and viruses.  Requirements for sample collection, preservation and replication of bacteria, fungi and viruses.  Methods of characterization of pathogenic fungi of veterinary importance including Aspergillus, Candida, Trichophyton, Mucor.  Histoplasma and Blastomyces.  Microbiology of food and water.

VPM 401: VETERINARY BACTERIOLOGY      (3 Units)
Isolation and identification of pathogenic bacteria of veterinary importance including Bacillus, Clostridium, Dermatophilus, Pasteurella, Staphylococcus, Streptococcus, Mycobacterium, Escherichia, Salmonella, Listeria, Brucella, Moraxella, Fusobacterium, Corynebacterium, Nocardia, Actinomyces, Actinobacillus, Pseudomonas, Shigella, Vibbrio, Bacteroides, Campylobacter, Leptospira, Borrelia, Treponema, Neisseria, Yersinia, Francisella, Bordetella, Acinetobacter, Histophilus, Burkholderia, Manniheimai and Mycoplasma.

VPM 402: VETERINARY VIROLOGY   (3 Units)
Morphology and taxonomy of viruses.  Culture of viruses in cell lines, embryonated eggs, brain tissue etc. Purification and assay of viruses.  Interferon and viral interference.  Pathogenic viruses of veterinary importance including Rinderpest, Peste des Petits Ruminants, Foot-and-mouth Disease, Poxes, Papillomatosis, Blue tongue, Rota-virus, Orf, Influenza, African Horse Sickness, Equine Infectious Anaemia, Equine Encephalomyelitis, Nigerian Horse Staggers, Rabies, African Swine Fever, Hog Cholera, Transmissible Gastroenteritis, Canine Distemper, Infectious Canine Hepatitis, Parvovirus, Feline panleucopaenia, New Castle Disease, Infectious Bursal Disease, Marek’s  Disease, Leucosis, Avian Encephalomyelitis, Avian Infectious Laryngotracheitis, Avian Infectious Bronchitis, EDS 76, Cowdria, Psittacosis, Ornithosis and Chlamydia.

VPM 403:    INTRODUCTORY VETERINARY IMMUNOLOGY   (2 Units)
Evolution of immunity.  Types of immunity.  Organs and cells involved in immune response.  Antigens, antibodies and their interactions. Complement system. Immune complexes.  Auto-immunity and auto-immune diseases.  Cytokines.  The major histocompatibility complex.  Genetic regulation of immune response. Hypersensitivity reactions, immunological tolerance, immuno-suppression and antigenic variation. Immune response to bacterial, fungal, viral and parasitic   infections and tumours. Vaccine and adjuvant types and functions. Application of biotechnology to vaccine production.

VETERINARY PARASITOLOGY

VPR 302:    INTRODUCTORY  VETERINARY PARASITOLOGY   (2 Units)
General characteristics and taxonomy of helminthes, protozoa and arthropods of veterinary importance. Economic importance of parasites of domestic animals and poultry.  Host immune mechanisms of parasite destruction.  Principles of the diagnosis, treatment and prevention of parasitic diseases.

VPR 401: VETERINARY HELMINTHOLOGY  (3 Units)
Diagnostic morphology, life cycle, pathogenicity and control of helminthes of veterinary importance including nematodes (Haemnochus, Ascarids, Strongylus, Oesophagostomum, trematodes (Fasciola, Paramphistomum, Dicrocoelium, Fascioloides) and Cestodes (Moniezia, Taenia, Coenurus, Avitellina and Diphyllobothrium).  Aphasmida.

VPR:  402: VETERINARY ENTOMOLOGY      (3 Units)
Diagnostic morphology, life cycle and economic impact of arthropods of veterinary importance including flies (Glossina, Tabanus, Stomoxys, Oestrus, Cullicoides, Simulium, Lucillia, Musca); lice (Damalinia, Haematopinus, Menacanthus, Linognathus); fleas (Ctenocephalides, Echdnophaga); ticks (Amblyomma, Boophilus, Hyalloma, Rhipicephalus, Haemaphysalis, Demacentor and Ixodes) and mange mites (Sarcoptes, Demodex, Otodectes, Psoroptes, Chorioptes).  Methods of control of arthropods of economic importance.  Development and management of inscticide resistance.

VPR 404: VETERINARY PROTOZOOLOGY   (2 Units)
Diagnostic morphology, life cycle, transmission, pathogenicity and control of protozoa of veterinary importance including arthropod-borne (Trypanosoma, Babesia, Anaplasma, Theileria, Haemobartonella, Plasmodium, Leishmania) and those with direct life cycle (Eimeria, Isospora, Toxoplasma, Besnoitia, Entamoeba, Trichomonas, Balantidium and Gardia).

VETERINARY BIOCHEMISTRY
VBB 201: BIOCHEMISTRY OF ENZYMES, CARBOHYDRATES AND LIPIDS  (3 Units)
Relevance of Biochemistry to Veterinary Medicine. Biochemistry of the living cell. PH and buffers.  Enzymes: nature, properties and functions; enzyme kinetcs; Allosteric effects;  Co-enzymes; structure and role in cellular metabolism. Enzyme assay in Clinical Vet. Medicine. Chemistry and biochemistry of carbohydrates of importance in Vet. Medicine;  Metabolism of carbohydrates: Glycolysis [Embden – Mayerhof pathway]. Metabolism of fructose and galactose.  Kreb’s (Citric Acid] Cycle, Glycoxylate cycle. Alternate pathways of carbohydrate oxidation.  The Uronic acid pathway.  Metabolism of glycogen. Disorders of carbohydrate metabolism. The Electron-transport chain and oxidative phosphorylation, Lipids; classification, chemistry and functions; digestion, absorption and transportation.  Lipoproteins etc.  Biosynthesis of fatty acids; the triacylglycerols.  Degradation of triacylglycerois, phospholipids and sphingolids.  B-oxidation of fatty acids. Ketone bodies and ketosis.  Metabolism of cholesterol.  Primary disorders of plasma lipoproteins (dyslipoproteinaemias] Biochemistry of the prostaglandins.

VBB 202:  BIOCHEMISTRY OF PROTEIN AND MOLECULAR BIOLOGY     
(3 Units)

Protein: classification, structure and functions. Amino acids, Peptides and peptide bond; essential and non-essential amino acids.  Metabolism of amino acids: transamination, oxidative  deamination, decarboxylation etc. Urea Cycle. Interconversions of threonine.  Inborn errors of metabolism.  Chemistry and structure of nucleic acids.  Catabolism of purines, pyrimidines and nucleotides; disorders of purine and pyrimdine metabolism. Plasma proteins, structure and functions; Blood clotting mechanisms, Iron; sources, absorption, distribution in the body and excretion; anaemia; haemochromatosis. Haemoglobin: structure,  properties and functions.  Metabolism of porphyrin.  Porphyrinurias and jaundice. Haemoglobinopathies:  HbS thalassemias, haemophilia etc. Gene cloning and application of recombinant DNA technology in Veterinary Medicine.  Immunoglobulins:  types, structures and  functions.  Antigens and antigenic determinants.  Retroviruses, molecular bases and involvement in cancer; proto-oncugenes and oncogens.  Translocation and gene arrangement in disease state of animals.


VBB 204: DRUG AND NUTRITIONAL BIOCHEMISTRy (2 Units)
Biochemical basis of drug, chemical and toxin metabolism and elimination, drug metabolizing enzymes.  Biochemistry of drugs of importance in Vet. Medicine including antibiotics, cytotoxi drugs, hypoglycaemic drugs, steroidal drugs.  General nutritional.  requirements of animals.  Monogastric and ruminant biochemistry.  Mechanism of nutrition-related diseases; nutrition and infection. Nutrient-drug interactions.  Effect of nutrition on membrane functions and immune response.  Water and the major ions.  Fluid intake and ouput.  Intracellular and extracellular fluids.  Vomiting, diarrhoea and dehydration and their correction.  Calcium, phosphorus and trace element ions metabolism and dysfunctions. Water soluble and fact soluble vitamins:  biochemical functions.
Chemistry and biochemistry of vision.

VBB 301:     BIOCHEMISTRY OF HORMONES AND DISEASE (2 Units)    
Molecular mechanisms of hormone action.  Biochemistry of hormones of hypothalamus, anterior and posterior pituary, parathyroid, thyroid, pancreatic islets, adrenal, pineal (epiphysis) glands, ovaries, testis, placenta, kidney, prostate, gastrointestinal tract and the brain. Biochemical basis of disease. Biochemistry of some common tropical animal disease e.g  Infections bursal disease (IBD), trypanosomosis. Biochemical basis of ageing.  Metabolic profiles of muscles, kidneys and liver.

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